Lotto has a long history of cycling sponsorship, they began sponsoring 1984 with Tönissteiner-Lotto-Mavic-Pecotex. In 1985, it became prime sponsor of a team bearing only its name. Walter Godefroot and Patrick Lefevere were early directeurs sportifs. The fusion of the Lotto-Adecco and Domo-Farm Frites teams for the start of the 2003 season created the current team and structure in the guise of Lotto-Domo.

Omega Pharma had previously been a co-sponsor of the Quick Step-Davitamon team in 2003 and 2004. Omega Pharma became the main sponsors in 2005, under their Davitamon brand name. The team name switched to Omega Pharma's Predictor brand name in 2007 and the Silence brand in 2008. From 2010 the team became known as Omega Pharma-Lotto, but this sponsor moved their financial support to the Quick-Step setup for the 2012 season.

Belisol became co-sponsors in 2012, and are a Belgian company making windows and doors and solar panels.